Optimizing thiopurine therapy in children with acute lymphoblastic leukemia: A promising “MINT” sequencing strategy and therapeutic “DNA-TG” monitoring

Thiopurines, including thioguanine (TG), 6-mercaptopurine (6-MP), and azathioprine (AZA), are extensively used in clinical practice in children with acute lymphoblastic leukemia (ALL) and inflammatory bowel diseases. However, the common adverse effects caused by myelosuppression and hepatotoxicity l...

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Detalles Bibliográficos
Autores principales: Guo, Hong-Li, Zhao, Yue-Tao, Wang, Wei-Jun, Dong, Na, Hu, Ya-Hui, Zhang, Yuan-Yuan, Chen, Feng, Zhou, Li, Li, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552076/
https://www.ncbi.nlm.nih.gov/pubmed/36238550
http://dx.doi.org/10.3389/fphar.2022.941182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552076/
https://www.ncbi.nlm.nih.gov/pubmed/36238550
http://dx.doi.org/10.3389/fphar.2022.941182

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