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Managing clustering effects and learning effects in the design and analysis of randomised surgical trials: a review of existing guidance

BACKGROUND: The complexities associated with delivering randomised surgical trials, such as clustering effects, by centre or surgeon, and surgical learning, are well known. Despite this, approaches used to manage these complexities, and opinions on these, vary. Guidance documents have been developed...

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Detalles Bibliográficos
Autores principales: Conroy, Elizabeth J., Blazeby, Jane M., Burnside, Girvan, Cook, Jonathan A., Gamble, Carrol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552436/
https://www.ncbi.nlm.nih.gov/pubmed/36221107
http://dx.doi.org/10.1186/s13063-022-06743-6