Etomoxir, a carnitine palmitoyltransferase 1 inhibitor, combined with temozolomide reduces stemness and invasiveness in patient-derived glioblastoma tumorspheres

INTRODUCTION: The importance of fatty acid oxidation (FAO) in the bioenergetics of glioblastoma (GBM) is being realized. Etomoxir (ETO), a carnitine palmitoyltransferase 1 (CPT1) inhibitor exerts cytotoxic effects in GBM, which involve interrupting the FAO pathway. We hypothesized that FAO inhibitio...

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Detalles Bibliográficos
Autores principales: Shim, Jin-Kyoung, Choi, Seonah, Yoon, Seon-Jin, Choi, Ran Joo, Park, Junseong, Lee, Eun Hee, Cho, Hye Joung, Lee, Suji, Teo, Wan-Yee, Moon, Ju Hyung, Kim, Hyun Sil, Kim, Eui Hyun, Cheong, Jae-Ho, Chang, Jong Hee, Yook, Jong In, Kang, Seok-Gu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552483/
https://www.ncbi.nlm.nih.gov/pubmed/36221088
http://dx.doi.org/10.1186/s12935-022-02731-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552483/
https://www.ncbi.nlm.nih.gov/pubmed/36221088
http://dx.doi.org/10.1186/s12935-022-02731-7

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