De novo sphingolipid biosynthesis necessitates detoxification in cancer cells

Sphingolipids play important signaling and structural roles in cells. Here, we find that during de novo sphingolipid biosynthesis, a toxic metabolite is formed with critical implications for cancer cell survival. The enzyme catalyzing the first step in this pathway, serine palmitoyltransferase compl...

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Detalles Bibliográficos
Autores principales: Spears, Meghan E., Lee, Namgyu, Hwang, Sunyoung, Park, Sung Jin, Carlisle, Anne E., Li, Rui, Doshi, Mihir B., Armando, Aaron M., Gao, Jenny, Simin, Karl, Zhu, Lihua Julie, Greer, Paul L., Quehenberger, Oswald, Torres, Eduardo M., Kim, Dohoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552870/
https://www.ncbi.nlm.nih.gov/pubmed/36170811
http://dx.doi.org/10.1016/j.celrep.2022.111415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552870/
https://www.ncbi.nlm.nih.gov/pubmed/36170811
http://dx.doi.org/10.1016/j.celrep.2022.111415

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