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De novo sphingolipid biosynthesis necessitates detoxification in cancer cells
Sphingolipids play important signaling and structural roles in cells. Here, we find that during de novo sphingolipid biosynthesis, a toxic metabolite is formed with critical implications for cancer cell survival. The enzyme catalyzing the first step in this pathway, serine palmitoyltransferase compl...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552870/ https://www.ncbi.nlm.nih.gov/pubmed/36170811 http://dx.doi.org/10.1016/j.celrep.2022.111415 |