Tubular-specific CDK12 knockout causes a defect in urine concentration due to premature cleavage of the slc12a1 gene

Cyclin-dependent kinase 12 (CDK12) plays a critical role in regulating gene transcription. CDK12 inhibition is a potential anticancer therapeutic strategy. However, several clinical trials have shown that CDK inhibitors might cause renal dysfunction and electrolyte disorders. CDK12 is abundant in re...

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Detalles Bibliográficos
Autores principales: Wang, Bin, Wang, Yao, Wen, Yi, Zhang, Yi-Lin, Ni, Wei-Jie, Tang, Tao-Tao, Cao, Jing-Yuan, Yin, Qing, Jiang, Wei, Yin, Di, Li, Zuo-Lin, Lv, Lin-Li, Liu, Bi-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552909/
https://www.ncbi.nlm.nih.gov/pubmed/35581939
http://dx.doi.org/10.1016/j.ymthe.2022.05.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552909/
https://www.ncbi.nlm.nih.gov/pubmed/35581939
http://dx.doi.org/10.1016/j.ymthe.2022.05.012

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