Self-amplifying loop of NF-κB and periostin initiated by PIEZO1 accelerates mechano-induced senescence of nucleus pulposus cells and intervertebral disc degeneration

Abnormal mechanical load is a main risk factor of intervertebral disc degeneration (IDD), and cellular senescence is a pathological change in IDD. In addition, extracellular matrix (ECM) stiffness promotes human nucleus pulposus cells (hNPCs) senescence. However, the molecular mechanism underlying m...

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Detalles Bibliográficos
Autores principales: Wu, Jinna, Chen, Yuyu, Liao, Zhiheng, Liu, Hengyu, Zhang, Shun, Zhong, Dongmei, Qiu, Xianjian, Chen, Taiqiu, Su, Deying, Ke, Xiaona, Wan, Yong, Zhou, Taifeng, Su, Peiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552911/
https://www.ncbi.nlm.nih.gov/pubmed/35619555
http://dx.doi.org/10.1016/j.ymthe.2022.05.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552911/
https://www.ncbi.nlm.nih.gov/pubmed/35619555
http://dx.doi.org/10.1016/j.ymthe.2022.05.021

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