Bilirubin as a Predictor of Complicated Appendicitis in a District General Hospital: A Retrospective Analysis

Aims The objectives of the study were to establish the function of bilirubin as a novel diagnostic tool for predicting complex appendicitis and to compare the impact of other variables such as white blood cell count (WCC), C-reactive protein (CRP), and neutrophil. Methods This retrospective, single-...

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Autores principales: Halaseh, Sattam A, Kostalas, Marcos, Kopec, Charles, Nimer, Abdullah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552955/
https://www.ncbi.nlm.nih.gov/pubmed/36237793
http://dx.doi.org/10.7759/cureus.29036
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author Halaseh, Sattam A
Kostalas, Marcos
Kopec, Charles
Nimer, Abdullah
author_facet Halaseh, Sattam A
Kostalas, Marcos
Kopec, Charles
Nimer, Abdullah
author_sort Halaseh, Sattam A
collection PubMed
description Aims The objectives of the study were to establish the function of bilirubin as a novel diagnostic tool for predicting complex appendicitis and to compare the impact of other variables such as white blood cell count (WCC), C-reactive protein (CRP), and neutrophil. Methods This retrospective, single-center cohort analysis included all patients admitted to Torbay General Hospital in Torquay, United Kingdom, between January 2020 and December 2020 with a clinical diagnosis of acute appendicitis. In addition to serum CRP, WCC, and neutrophil, serum bilirubin and other liver enzymes were obtained from the patients’ blood on admission. Results The quantitative analysis included 174 patients from the group that remained. The large majority of the sample consisted of adults and males (77% and 51.7%, respectively). Overall, 49.4% of participants in the study were diagnosed with complicated appendicitis; 74.7% of adults had complicated appendicitis, with 58.6% being male. In 68.6% of cases, perforated appendicitis was the most prevalent form of complicated appendicitis. Patients with complicated appendicitis had significantly higher WCC, neutrophil, and CRP levels than those with uncomplicated appendicitis (14.15 vs. 12.88, p = 0.016; 11.63 vs. 10.19, p = 0.007; and (89.28 vs. 40.65, p = 0.0001, respectively).. The significantly greater alkaline phosphatase and total serum bilirubin discrepancies were observed in patients with complicated appendicitis. There were statistically significant differences in the means of the patients: (18.46 vs. 10.98, p = 0.0001 and 110.64 vs. 102.24, p = 0.033). Conclusion Serum bilirubin is a crucial diagnostic aid for determining the existence of complicated appendicitis.
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spelling pubmed-95529552022-10-12 Bilirubin as a Predictor of Complicated Appendicitis in a District General Hospital: A Retrospective Analysis Halaseh, Sattam A Kostalas, Marcos Kopec, Charles Nimer, Abdullah Cureus Pathology Aims The objectives of the study were to establish the function of bilirubin as a novel diagnostic tool for predicting complex appendicitis and to compare the impact of other variables such as white blood cell count (WCC), C-reactive protein (CRP), and neutrophil. Methods This retrospective, single-center cohort analysis included all patients admitted to Torbay General Hospital in Torquay, United Kingdom, between January 2020 and December 2020 with a clinical diagnosis of acute appendicitis. In addition to serum CRP, WCC, and neutrophil, serum bilirubin and other liver enzymes were obtained from the patients’ blood on admission. Results The quantitative analysis included 174 patients from the group that remained. The large majority of the sample consisted of adults and males (77% and 51.7%, respectively). Overall, 49.4% of participants in the study were diagnosed with complicated appendicitis; 74.7% of adults had complicated appendicitis, with 58.6% being male. In 68.6% of cases, perforated appendicitis was the most prevalent form of complicated appendicitis. Patients with complicated appendicitis had significantly higher WCC, neutrophil, and CRP levels than those with uncomplicated appendicitis (14.15 vs. 12.88, p = 0.016; 11.63 vs. 10.19, p = 0.007; and (89.28 vs. 40.65, p = 0.0001, respectively).. The significantly greater alkaline phosphatase and total serum bilirubin discrepancies were observed in patients with complicated appendicitis. There were statistically significant differences in the means of the patients: (18.46 vs. 10.98, p = 0.0001 and 110.64 vs. 102.24, p = 0.033). Conclusion Serum bilirubin is a crucial diagnostic aid for determining the existence of complicated appendicitis. Cureus 2022-09-11 /pmc/articles/PMC9552955/ /pubmed/36237793 http://dx.doi.org/10.7759/cureus.29036 Text en Copyright © 2022, Halaseh et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pathology
Halaseh, Sattam A
Kostalas, Marcos
Kopec, Charles
Nimer, Abdullah
Bilirubin as a Predictor of Complicated Appendicitis in a District General Hospital: A Retrospective Analysis
title Bilirubin as a Predictor of Complicated Appendicitis in a District General Hospital: A Retrospective Analysis
title_full Bilirubin as a Predictor of Complicated Appendicitis in a District General Hospital: A Retrospective Analysis
title_fullStr Bilirubin as a Predictor of Complicated Appendicitis in a District General Hospital: A Retrospective Analysis
title_full_unstemmed Bilirubin as a Predictor of Complicated Appendicitis in a District General Hospital: A Retrospective Analysis
title_short Bilirubin as a Predictor of Complicated Appendicitis in a District General Hospital: A Retrospective Analysis
title_sort bilirubin as a predictor of complicated appendicitis in a district general hospital: a retrospective analysis
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552955/
https://www.ncbi.nlm.nih.gov/pubmed/36237793
http://dx.doi.org/10.7759/cureus.29036
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