Generative and interpretable machine learning for aptamer design and analysis of in vitro sequence selection

Selection protocols such as SELEX, where molecules are selected over multiple rounds for their ability to bind to a target of interest, are popular methods for obtaining binders for diagnostic and therapeutic purposes. We show that Restricted Boltzmann Machines (RBMs), an unsupervised two-layer neur...

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Detalles Bibliográficos
Autores principales: Di Gioacchino, Andrea, Procyk, Jonah, Molari, Marco, Schreck, John S., Zhou, Yu, Liu, Yan, Monasson, Rémi, Cocco, Simona, Šulc, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553063/
https://www.ncbi.nlm.nih.gov/pubmed/36174101
http://dx.doi.org/10.1371/journal.pcbi.1010561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553063/
https://www.ncbi.nlm.nih.gov/pubmed/36174101
http://dx.doi.org/10.1371/journal.pcbi.1010561

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