Mitochondrial Dysfunction and Pharmacodynamics of Mitofusin Activation in Murine Charcot-Marie-Tooth Disease Type 2A

Mitofusin (MFN) 1 and MFN2 are dynamin GTPase family mitochondrial proteins that mediate mitochondrial fusion requiring MFN conformational shifts, formation of macromolecular complexes on and between mitochondria, and GTP hydrolysis. Damaging MFN2 mutations cause an untreatable, largely pediatric pr...

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Detalles Bibliográficos
Autores principales: Franco, Antonietta, Dang, Xiawei, Zhang, Lihong, Molinoff, Perry B., Dorn, Gerald W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2022
Materias:
Drug Discovery and Translational Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553116/
https://www.ncbi.nlm.nih.gov/pubmed/36507849
http://dx.doi.org/10.1124/jpet.122.001332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553116/
https://www.ncbi.nlm.nih.gov/pubmed/36507849
http://dx.doi.org/10.1124/jpet.122.001332

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