Lack of UBE3A-Mediated Regulation of Synaptic SK2 Channels Contributes to Learning and Memory Impairment in the Female Mouse Model of Angelman Syndrome

Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by severe developmental delay, motor impairment, language and cognition deficits, and often with increased seizure activity. AS is caused by deficiency of UBE3A, which is both an E3 ligase and a cofactor for transcriptional r...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Jiandong, Liu, Yan, Hao, Xiaoning, Baudry, Michel, Bi, Xiaoning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553421/
https://www.ncbi.nlm.nih.gov/pubmed/36237484
http://dx.doi.org/10.1155/2022/3923384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553421/
https://www.ncbi.nlm.nih.gov/pubmed/36237484
http://dx.doi.org/10.1155/2022/3923384

Ejemplares similares