Altered Bioavailability and Pharmacokinetics in Crohn’s Disease: Capturing Systems Parameters for PBPK to Assist with Predicting the Fate of Orally Administered Drugs

BACKGROND AND OBJECTIVE: Crohn’s disease (CD) is a chronic inflammatory bowel disease that affects a wide age range. Hence, CD patients receive a variety of drugs over their life beyond those used for CD itself. The changes to the integrity of the intestine and its drug metabolising enzymes and tran...

Descripción completa

Detalles Bibliográficos
Autores principales: Alrubia, Sarah, Mao, Jialin, Chen, Yuan, Barber, Jill, Rostami-Hodjegan, Amin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Systematic Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553790/
https://www.ncbi.nlm.nih.gov/pubmed/36056298
http://dx.doi.org/10.1007/s40262-022-01169-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553790/
https://www.ncbi.nlm.nih.gov/pubmed/36056298
http://dx.doi.org/10.1007/s40262-022-01169-4

Ejemplares similares