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S100A8-mediated metabolic adaptation controls HIV-1 persistence in macrophages in vivo

HIV-1 eradication is hindered by viral persistence in cell reservoirs, established not only in circulatory CD4(+)T-cells but also in tissue-resident macrophages. The nature of macrophage reservoirs and mechanisms of persistence despite combined anti-retroviral therapy (cART) remain unclear. Using ge...

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Detalles Bibliográficos
Autores principales: Real, Fernando, Zhu, Aiwei, Huang, Boxin, Belmellat, Ania, Sennepin, Alexis, Vogl, Thomas, Ransy, Céline, Revol, Marc, Arrigucci, Riccardo, Lombès, Anne, Roth, Johannes, Gennaro, Maria Laura, Bouillaud, Frédéric, Cristofari, Sarra, Bomsel, Morgane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553955/
https://www.ncbi.nlm.nih.gov/pubmed/36220814
http://dx.doi.org/10.1038/s41467-022-33401-x