Caspase-1 inhibition improves cognition without significantly altering amyloid and inflammation in aged Alzheimer disease mice

Human genetic and animal model studies indicate that brain microglial inflammation is a primary driver of cognitive impairment in Alzheimer Disease (AD). Inflammasome-activated Caspase-1 (Casp1) is associated with both AD microglial inflammation and neuronal degeneration. In mice, Casp1 genetic abla...

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Detalles Bibliográficos
Autores principales: Flores, Joseph, Fillion, Marie-Lyne, LeBlanc, Andréa C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553979/
https://www.ncbi.nlm.nih.gov/pubmed/36220815
http://dx.doi.org/10.1038/s41419-022-05290-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553979/
https://www.ncbi.nlm.nih.gov/pubmed/36220815
http://dx.doi.org/10.1038/s41419-022-05290-x

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