Squalene epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis

OBJECTIVE: Aberrant lipid metabolism is a hallmark of colorectal cancer (CRC). Squalene epoxidase (SQLE), a rate-limiting enzyme in cholesterol biosynthesis, is upregulated in CRC. Here, we aim to determine oncogenic function of SQLE and its interplay with gut microbiota in promoting colorectal tumo...

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Detalles Bibliográficos
Autores principales: Li, Chuangen, Wang, Yong, Liu, Dabin, Wong, Chi Chun, Coker, Olabisi Oluwabukola, Zhang, Xiang, Liu, Changan, Zhou, Yunfei, Liu, Yali, Kang, Wei, To, Ka Fai, Sung, Joseph JY, Yu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Colon
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554078/
https://www.ncbi.nlm.nih.gov/pubmed/35232776
http://dx.doi.org/10.1136/gutjnl-2021-325851

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554078/
https://www.ncbi.nlm.nih.gov/pubmed/35232776
http://dx.doi.org/10.1136/gutjnl-2021-325851

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