The effect of AUT00206, a Kv3 potassium channel modulator, on dopamine synthesis capacity and the reliability of [(18)F]-FDOPA imaging in schizophrenia

BACKGROUND: Current treatments for schizophrenia act directly on dopamine (DA) receptors but are ineffective for many patients, highlighting the need to develop new treatment approaches. Striatal DA dysfunction, indexed using [(18)F]-FDOPA imaging, is linked to the pathoetiology of schizophrenia. We...

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Detalles Bibliográficos
Autores principales: Angelescu, Ilinca, Kaar, Stephen J, Marques, Tiago Reis, Borgan, Faith, Veronesse, Mattia, Sharman, Alice, Sajjala, Anil, Deakin, Bill, Hutchison, John, Large, Charles, Howes, Oliver D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554157/
https://www.ncbi.nlm.nih.gov/pubmed/36164687
http://dx.doi.org/10.1177/02698811221122031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554157/
https://www.ncbi.nlm.nih.gov/pubmed/36164687
http://dx.doi.org/10.1177/02698811221122031

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