Cargando…

The effect of AUT00206, a Kv3 potassium channel modulator, on dopamine synthesis capacity and the reliability of [(18)F]-FDOPA imaging in schizophrenia

BACKGROUND: Current treatments for schizophrenia act directly on dopamine (DA) receptors but are ineffective for many patients, highlighting the need to develop new treatment approaches. Striatal DA dysfunction, indexed using [(18)F]-FDOPA imaging, is linked to the pathoetiology of schizophrenia. We...

Descripción completa

Detalles Bibliográficos
Autores principales:	Angelescu, Ilinca, Kaar, Stephen J, Marques, Tiago Reis, Borgan, Faith, Veronesse, Mattia, Sharman, Alice, Sajjala, Anil, Deakin, Bill, Hutchison, John, Large, Charles, Howes, Oliver D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2022
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554157/ https://www.ncbi.nlm.nih.gov/pubmed/36164687 http://dx.doi.org/10.1177/02698811221122031

Ejemplares similares

The effects of AUT00206, a novel Kv3.1/3.2 potassium channel modulator, on task-based reward system activation: a test of mechanism in schizophrenia
por: Kaar, Stephen J., et al.
Publicado: (2022)

An automatic analysis framework for FDOPA PET neuroimaging
por: Nordio, Giovanna, et al.
Publicado: (2023)

Pre-frontal parvalbumin interneurons in schizophrenia: a meta-analysis of post-mortem studies
por: Kaar, Stephen J., et al.
Publicado: (2019)

Evaluation of Intraperitoneal [(18)F]-FDOPA Administration for Micro-PET Imaging in Mice and Assessment of the Effect of Subchronic Ketamine Dosing on Dopamine Synthesis Capacity
por: Halff, Els F., et al.
Publicado: (2022)

Enzyme inhibition of dopamine metabolism alters 6-[(18)F]FDOPA uptake in orthotopic pancreatic adenocarcinoma
por: Tuomela, Johanna, et al.
Publicado: (2013)

GABA-A receptor differences in schizophrenia: a positron emission tomography study using [(11)C]Ro154513
por: Marques, Tiago Reis, et al.
Publicado: (2020)

Vaccinium Crassifolium Aut Repens
Publicado: (1880)

Membrane Recruitment of Aut7p in the Autophagy and Cytoplasm to Vacuole Targeting Pathways Requires Aut1p, Aut2p, and the Autophagy Conjugation Complex
por: Kim, John, et al.
Publicado: (2001)

Automated Data Quality Control in FDOPA brain PET Imaging using Deep Learning
por: Pontoriero, Antonella D., et al.
Publicado: (2021)

Role of Kv1 Potassium Channels in Regulating Dopamine Release and Presynaptic D2 Receptor Function
por: Martel, Philippe, et al.
Publicado: (2011)

Neuronal Migration and AUTS2 Syndrome
por: Hori, Kei, et al.
Publicado: (2017)

A Process Gateway between the PS and LINAC/LEAR Control Networks: 'Aut inveniam viam aut faciam'
por: Casalegno, L, et al.
Publicado: (1985)

AutA and AutR, Two Novel Global Transcriptional Regulators, Facilitate Avian Pathogenic Escherichia coli Infection
por: Zhuge, Xiangkai, et al.
Publicado: (2016)

A potential biomarker for treatment stratification in psychosis: evaluation of an [(18)F] FDOPA PET imaging approach
por: Veronese, Mattia, et al.
Publicado: (2020)

Neutrophil lymphocyte ratio in aute renal failure
por: Erdem, E.
Publicado: (2015)

Striatal dopamine synthesis capacity in autism spectrum disorder and its relation with social defeat: an [(18)F]-FDOPA PET/CT study
por: Schalbroeck, Rik, et al.
Publicado: (2021)

A Mouse Mutation That Dysregulates Neighboring Galnt17 and Auts2 Genes Is Associated with Phenotypes Related to the Human AUTS2 Syndrome
por: Weisner, P. Anne, et al.
Publicado: (2019)

Optimization of time frame binning for FDOPA uptake quantification in glioma
por: Girard, Antoine, et al.
Publicado: (2020)

Additive Value of Dynamic FDOPA PET/CT for Glioma Grading
por: Girard, Antoine, et al.
Publicado: (2021)

N-Methyl-D-Aspartate Receptor binding in First-Episode Psychosis: A PET brain imaging study
por: Beck, Katherine, et al.
Publicado: (2021)

Potassium-dependent Changes in the Conformation of the Kv2.1 Potassium Channel Pore
por: Immke, David, et al.
Publicado: (1999)

Bejárat s aut hoz hasonl a nagy hadronütköztet
Publicado: (2009)

Characterization and Distribution of the autB Gene in Neisseria meningitidis
por: Zhang, Aiyu, et al.
Publicado: (2017)

AUTS2 Syndrome: Molecular Mechanisms and Model Systems
por: Biel, Alecia, et al.
Publicado: (2022)

Novel insights regarding the measurement properties of the SCOPA-AUT
por: Westergren, Albert, et al.
Publicado: (2022)

AutDB: a gene reference resource for autism research
por: Basu, Saumyendra N., et al.
Publicado: (2009)

AutDB: a platform to decode the genetic architecture of autism
por: Pereanu, Wayne, et al.
Publicado: (2018)

AUTS2 Gene: Keys to Understanding the Pathogenesis of Neurodevelopmental Disorders
por: Hori, Kei, et al.
Publicado: (2021)

Extracellular redox sensitivity of Kv1.2 potassium channels
por: Baronas, Victoria A., et al.
Publicado: (2017)

The dopamine transporter antiports potassium to increase the uptake of dopamine
por: Schmidt, Solveig G., et al.
Publicado: (2022)

The effects of molar activity on [(18)F]FDOPA uptake in patients with neuroendocrine tumors
por: Stormezand, Gilles N., et al.
Publicado: (2021)

The relationship between cortical glutamate and striatal dopamine in first-episode psychosis: a cross-sectional multimodal PET and magnetic resonance spectroscopy imaging study
por: Jauhar, Sameer, et al.
Publicado: (2018)

The relationship between striatal dopamine and anterior cingulate glutamate in first episode psychosis changes with antipsychotic treatment
por: Jauhar, Sameer, et al.
Publicado: (2023)

Animal model integration to AutDB, a genetic database for autism
por: Kumar, Ajay, et al.
Publicado: (2011)

AUTS2 confers gene activation to Polycomb group proteins in the CNS
por: Gao, Zhonghua, et al.
Publicado: (2014)

AUTS2 Regulation of Synapses for Proper Synaptic Inputs and Social Communication
por: Hori, Kei, et al.
Publicado: (2020)

Cerebral organoids containing an AUTS2 missense variant model microcephaly
por: Fair, Summer R, et al.
Publicado: (2022)

Association between cannabinoid 1 receptor availability and glutamate levels in healthy controls and drug-free patients with first episode psychosis: a multi-modal PET and 1H-MRS study
por: Borgan, Faith, et al.
Publicado: (2020)

Modulation of the Kv1.3 Potassium Channel by Receptor Tyrosine Kinases
por: Bowlby, Mark R., et al.
Publicado: (1997)

Kv7/M-type potassium channels in rat skin keratinocytes
por: Reilly, Joanne M., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_kp987mt1el3d2jteu2odrvfk3a