Cargando…

Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein

Neutralizing monoclonal antibodies (mAbs) against highly pathogenic coronaviruses represent promising candidates for clinical intervention. Here, we isolated a potent neutralizing monoclonal antibody, MERS-S41, from a yeast displayed scFv library using the S protein as a bait. To uncover the neutral...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Shuyuan, Jia, Wenxv, Zeng, Jianwei, Li, Mingxi, Wang, Ziyi, Zhou, Haixia, Zhang, Linqi, Wang, Xinquan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554411/ https://www.ncbi.nlm.nih.gov/pubmed/36246239 http://dx.doi.org/10.3389/fmicb.2022.988298

Ejemplares similares

Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein
por: Zhou, Haixia, et al.
Publicado: (2019)

Crystallization and Structural Determination of the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein
por: Zhou, Haixia, et al.
Publicado: (2019)

Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein
por: Zhang, Senyan, et al.
Publicado: (2018)

Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution
por: Zhang, Shuyuan, et al.
Publicado: (2021)

Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27
por: Yu, Xiaojuan, et al.
Publicado: (2015)

Developing Graphene Grids for Cryoelectron Microscopy
por: Fan, Hongcheng, et al.
Publicado: (2022)

The spike glycoprotein of highly pathogenic human coronaviruses: structural insights for understanding infection, evolution and inhibition
por: Qiao, Shuyuan, et al.
Publicado: (2022)

Cryoelectronics
por: Jolly, William P
Publicado: (1972)

The cryoelectron microscopy structure of the human CDK-activating kinase
por: Greber, Basil J., et al.
Publicado: (2020)

Purification and cryoelectron microscopy structure determination of human V-ATPase
por: Wang, Longfei, et al.
Publicado: (2021)

Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection
por: Jia, Wenxu, et al.
Publicado: (2019)

Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding
por: Gui, Miao, et al.
Publicado: (2017)

Three-dimensional structures of the flagellar dynein–microtubule complex by cryoelectron microscopy
por: Oda, Toshiyuki, et al.
Publicado: (2007)

Three-dimensional structure of rhesus rotavirus by cryoelectron microscopy and image reconstruction
Publicado: (1990)

Structural Study of Heterogeneous Biological Samples by Cryoelectron Microscopy and Image Processing
por: White, H. E., et al.
Publicado: (2017)

The Cryoelectron Microscopy Structure of the Type 1 Chaperone-Usher Pilus Rod
por: Hospenthal, Manuela K., et al.
Publicado: (2017)

Contributions of single-particle cryoelectron microscopy toward fighting COVID-19
por: Rapp, Micah, et al.
Publicado: (2022)

Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution
por: Yu, Jinfang, et al.
Publicado: (2020)

Determining structures in a native environment using single-particle cryoelectron microscopy images
por: Cheng, Jing, et al.
Publicado: (2021)

Three-dimensional structure of the acetylcholine receptor by cryoelectron microscopy and helical image reconstruction
Publicado: (1990)

Conformational changes in tubulin in GMPCPP and GDP-taxol microtubules observed by cryoelectron microscopy
por: Yajima, Hiroaki, et al.
Publicado: (2012)

Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4
por: Wang, Nianshuang, et al.
Publicado: (2013)

Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2
por: Zhang, Shuyuan, et al.
Publicado: (2022)

Cryoelectron Tomography of HIV-1 Envelope Spikes: Further Evidence for Tripod-Like Legs
por: Zhu, Ping, et al.
Publicado: (2008)

Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein
por: Widjaja, Ivy, et al.
Publicado: (2019)

Determination of the alpha-actinin-binding site on actin filaments by cryoelectron microscopy and image analysis
Publicado: (1994)

Two-dimensional structure of the light-harvesting chlorophyll a/b complex by cryoelectron microscopy
Publicado: (1988)

Cryoelectron Microscopy Structures of AdeB Illuminate Mechanisms of Simultaneous Binding and Exporting of Substrates
por: Morgan, Christopher E., et al.
Publicado: (2021)

Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors
por: Park, Young-Jun, et al.
Publicado: (2019)

Chromatin conformation and salt-induced compaction: three-dimensional structural information from cryoelectron microscopy
Publicado: (1995)

Variations in Spike Glycoprotein Gene of MERS-CoV, South Korea, 2015
por: Kim, Dae-Won, et al.
Publicado: (2016)

Cryoelectron tomography of radial spokes in cilia and flagella
por: Pigino, Gaia, et al.
Publicado: (2011)

Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy
por: Peña, Alejandro, et al.
Publicado: (2020)

Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy
por: Peña, Alejandro, et al.
Publicado: (2021)

Cryoelectron microscopy of Na(+),K(+)-ATPase in the two E2P states with and without cardiotonic steroids
por: Kanai, Ryuta, et al.
Publicado: (2022)

A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein
por: Li, Yan, et al.
Publicado: (2015)

Conformational switching and flexibility in cobalamin-dependent methionine synthase studied by small-angle X-ray scattering and cryoelectron microscopy
por: Watkins, Maxwell B., et al.
Publicado: (2023)

Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody
por: Chandramouli, Sumana, et al.
Publicado: (2015)

Structure of the rabies virus glycoprotein trimer bound to a prefusion-specific neutralizing antibody
por: Callaway, Heather M., et al.
Publicado: (2022)

Brush Border Myosin–I Structure and ADP-dependent Conformational Changes Revealed by Cryoelectron Microscopy and Image Analysis
por: Jontes, James D., et al.
Publicado: (1997)

Cannot write session to /tmp/vufind_sessions/sess_nuvr885n8h25h7g2qu7s7dit1i