Physiologically-based pharmacokinetic modelling and dosing evaluation of gentamicin in neonates using PhysPK

Each year, infections caused around the 25% of neonatal deaths. Early empirical treatments help to reduce this mortality, although optimized dosing regimens are still lacking. The aims were to develop and validate a gentamicin physiologically-based pharmacokinetic (PBPK) model and then potentially e...

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Detalles Bibliográficos
Autores principales: Zazo, Hinojal, Lagarejos, Eduardo, Prado-Velasco, Manuel, Sánchez-Herrero, Sergio, Serna, Jenifer, Rueda-Ferreiro, Almudena, Martín-Suárez, Ana, Calvo, M. Victoria, Pérez-Blanco, Jonás Samuel, Lanao, José M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554458/
https://www.ncbi.nlm.nih.gov/pubmed/36249803
http://dx.doi.org/10.3389/fphar.2022.977372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554458/
https://www.ncbi.nlm.nih.gov/pubmed/36249803
http://dx.doi.org/10.3389/fphar.2022.977372

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