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L-cysteine methyl ester overcomes the deleterious effects of morphine on ventilatory parameters and arterial blood-gas chemistry in unanesthetized rats

We are developing a series of thiolesters that produce an immediate and sustained reversal of the deleterious effects of opioids, such as morphine and fentanyl, on ventilation without diminishing the antinociceptive effects of these opioids. We report here the effects of systemic injections of L-cys...

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Detalles Bibliográficos
Autores principales: Getsy, Paulina M., Baby, Santhosh M., May, Walter J., Bates, James N., Ellis, Christopher R., Feasel, Michael G., Wilson, Christopher G., Lewis, Tristan H. J., Gaston, Benjamin, Hsieh, Yee-Hsee, Lewis, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554613/
https://www.ncbi.nlm.nih.gov/pubmed/36249760
http://dx.doi.org/10.3389/fphar.2022.968378