The High Mutational Sensitivity of ccdA Antitoxin Is Linked to Codon Optimality

Deep mutational scanning studies suggest that synonymous mutations are typically silent and that most exposed, nonactive-site residues are tolerant to mutations. Here, we show that the ccdA antitoxin component of the Escherichia coli ccdAB toxin–antitoxin system is unusually sensitive to mutations w...

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Detalles Bibliográficos
Autores principales: Chandra, Soumyanetra, Gupta, Kritika, Khare, Shruti, Kohli, Pehu, Asok, Aparna, Mohan, Sonali Vishwa, Gowda, Harsha, Varadarajan, Raghavan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555053/
https://www.ncbi.nlm.nih.gov/pubmed/36069948
http://dx.doi.org/10.1093/molbev/msac187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555053/
https://www.ncbi.nlm.nih.gov/pubmed/36069948
http://dx.doi.org/10.1093/molbev/msac187

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