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The High Mutational Sensitivity of ccdA Antitoxin Is Linked to Codon Optimality
Deep mutational scanning studies suggest that synonymous mutations are typically silent and that most exposed, nonactive-site residues are tolerant to mutations. Here, we show that the ccdA antitoxin component of the Escherichia coli ccdAB toxin–antitoxin system is unusually sensitive to mutations w...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555053/ https://www.ncbi.nlm.nih.gov/pubmed/36069948 http://dx.doi.org/10.1093/molbev/msac187 |