Cargando…

The Spike-Stabilizing D614G Mutation Interacts with S1/S2 Cleavage Site Mutations To Promote the Infectious Potential of SARS-CoV-2 Variants

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remained genetically stable during the first 3 months of the pandemic, before acquiring a D614G spike mutation that rapidly spread worldwide and then generating successive waves of viral variants with increasingly high transmissibility. We...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gellenoncourt, Stacy, Saunders, Nell, Robinot, Rémy, Auguste, Lucas, Rajah, Maaran Michael, Kervevan, Jérôme, Jeger-Madiot, Raphaël, Staropoli, Isabelle, Planchais, Cyril, Mouquet, Hugo, Buchrieser, Julian, Schwartz, Olivier, Chakrabarti, Lisa A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Virus-Cell Interactions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555207/ https://www.ncbi.nlm.nih.gov/pubmed/36121299 http://dx.doi.org/10.1128/jvi.01301-22

Ejemplares similares

SARS‐CoV‐2 Alpha, Beta, and Delta variants display enhanced Spike‐mediated syncytia formation
por: Rajah, Maaran Michael, et al.
Publicado: (2021)

Divergent adaptive immune responses define two types of long COVID
por: Kervevan, Jérôme, et al.
Publicado: (2023)

Mutation of the Putative Immunosuppressive Domain of the Retroviral Envelope Glycoprotein Compromises Infectivity
por: Eksmond, Urszula, et al.
Publicado: (2017)

Multiple Pathways To Avoid Beta Interferon Sensitivity of HIV-1 by Mutations in Capsid
por: Sultana, Tahmina, et al.
Publicado: (2019)

Cleavage of 14-3-3ε by the enteroviral 3C protease dampens RIG-I-mediated antiviral signaling
por: Andrews, Daniel D. T., et al.
Publicado: (2023)

Host Range Expansion of Shigella Phage Sf6 Evolves through Point Mutations in the Tailspike
por: Subramanian, Sundharraman, et al.
Publicado: (2022)

Chemical Evolution of Rhinovirus Identifies Capsid-Destabilizing Mutations Driving Low-pH-Independent Genome Uncoating
por: Murer, Luca, et al.
Publicado: (2022)

Potential Differences in Cleavage of the S Protein and Type 1 Interferon Together Control Human Coronavirus Infection, Propagation, and Neuropathology within the Central Nervous System
por: Le Coupanec, Alain, et al.
Publicado: (2021)

Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling
por: Frolova, Elena I., et al.
Publicado: (2022)

SARS-CoV-2 Spike Furin Cleavage Site and S2′ Basic Residues Modulate the Entry Process in a Host Cell-Dependent Manner
por: Lavie, Muriel, et al.
Publicado: (2022)

Mutations in the Spike Protein of Middle East Respiratory Syndrome Coronavirus Transmitted in Korea Increase Resistance to Antibody-Mediated Neutralization
por: Kleine-Weber, Hannah, et al.
Publicado: (2019)

Mechanism of Cross-Resistance to Fusion Inhibitors Conferred by the K394R Mutation in Respiratory Syncytial Virus Fusion Protein
por: Tang, Wei, et al.
Publicado: (2021)

Natural and Recombinant SARS-CoV-2 Isolates Rapidly Evolve In Vitro to Higher Infectivity through More Efficient Binding to Heparan Sulfate and Reduced S1/S2 Cleavage
por: Shiliaev, Nikita, et al.
Publicado: (2021)

Species-Specific Molecular Barriers to SARS-CoV-2 Replication in Bat Cells
por: Aicher, Sophie-Marie, et al.
Publicado: (2022)

V367F Mutation in SARS-CoV-2 Spike RBD Emerging during the Early Transmission Phase Enhances Viral Infectivity through Increased Human ACE2 Receptor Binding Affinity
por: Ou, Junxian, et al.
Publicado: (2021)

Role of E6 in Maintaining the Basal Cell Reservoir during Productive Papillomavirus Infection
por: Saunders-Wood, Taylor, et al.
Publicado: (2022)

The Mechanism and Consequences of SARS-CoV-2 Spike-Mediated Fusion and Syncytia Formation
por: Rajah, Maaran Michael, et al.
Publicado: (2022)

Low CCR5 expression protects HIV-specific CD4+ T cells of elite controllers from viral entry
por: Claireaux, Mathieu, et al.
Publicado: (2022)

By Binding CD80 and CD86, the Vaccinia Virus M2 Protein Blocks Their Interactions with both CD28 and CTLA4 and Potentiates CD80 Binding to PD-L1
por: Kleinpeter, Patricia, et al.
Publicado: (2019)

Syncytia formation by SARS‐CoV‐2‐infected cells
por: Buchrieser, Julian, et al.
Publicado: (2020)

Syncytia formation by SARS‐CoV‐2‐infected cells
por: Buchrieser, Julian, et al.
Publicado: (2021)

Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunctional antibodies
por: Dufloo, Jérémy, et al.
Publicado: (2021)

Adeno-Associated Virus Rep Represses the Human Integration Site Promoter by Two Pathways That Are Similar to Those Required for the Regulation of the Viral p5 Promoter
por: Dutheil, Nathalie, et al.
Publicado: (2014)

Counteracting Effects of Cellular Notch and Epstein-Barr Virus EBNA2: Implications for Stromal Effects on Virus-Host Interactions
por: Rowe, Martin, et al.
Publicado: (2014)

Human Rhinovirus 16 Causes Golgi Apparatus Fragmentation without Blocking Protein Secretion
por: Mousnier, Aurelie, et al.
Publicado: (2014)

Genogroup IV and VI Canine Noroviruses Interact with Histo-Blood Group Antigens
por: Caddy, Sarah, et al.
Publicado: (2014)

Host Factors That Interact with the Pestivirus N-Terminal Protease, N(pro), Are Components of the Ribonucleoprotein Complex
por: Jefferson, Matthew, et al.
Publicado: (2014)

Simultaneous Neutralization and Innate Immune Detection of a Replicating Virus by TRIM21
por: Watkinson, R. E., et al.
Publicado: (2013)

The Role of Protein Kinase A Regulation of the E6 PDZ-Binding Domain during the Differentiation-Dependent Life Cycle of Human Papillomavirus Type 18
por: Delury, Craig P., et al.
Publicado: (2013)

Foot-and-Mouth Disease Virus 3C Protease Induces Fragmentation of the Golgi Compartment and Blocks Intra-Golgi Transport
por: Zhou, Zhigang, et al.
Publicado: (2013)

An Unbiased Genetic Screen Reveals the Polygenic Nature of the Influenza Virus Anti-Interferon Response
por: Pérez-Cidoncha, Maite, et al.
Publicado: (2014)

TRAF2 Facilitates Vaccinia Virus Replication by Promoting Rapid Virus Entry
por: Haga, Ismar R., et al.
Publicado: (2014)

A Triple-Arginine Motif in the Amino-Terminal Domain and Oligomerization Are Required for HIV-1 Inhibition by Human MX2
por: Goujon, Caroline, et al.
Publicado: (2015)

Hepatitis C Virus Attenuates Mitochondrial Lipid β-Oxidation by Downregulating Mitochondrial Trifunctional-Protein Expression
por: Amako, Yutaka, et al.
Publicado: (2015)

Requirement for Chloride Channel Function during the Hepatitis C Virus Life Cycle
por: Igloi, Zsofia, et al.
Publicado: (2015)

In Vitro Reactivation of Replication-Competent and Infectious HIV-1 by Histone Deacetylase Inhibitors
por: Banga, Riddhima, et al.
Publicado: (2016)

Remote Activation of Host Cell DNA Synthesis in Uninfected Cells Signaled by Infected Cells in Advance of Virus Transmission
por: Schmidt, Nora, et al.
Publicado: (2015)

Contact-Induced Mitochondrial Polarization Supports HIV-1 Virological Synapse Formation
por: Groppelli, Elisabetta, et al.
Publicado: (2014)

Merkel Cell Polyomavirus Small T Antigen Mediates Microtubule Destabilization To Promote Cell Motility and Migration
por: Knight, Laura M., et al.
Publicado: (2014)

Sapovirus Translation Requires an Interaction between VPg and the Cap Binding Protein eIF4E
por: Hosmillo, Myra, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_i84kivlvsm4ooklf9e877l6ff6