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Dual reactivity disulfide bridging reagents; enabling new approaches to antibody fragment bioconjugation
Disulfide bridging, also known as disulfide stapling, is a powerful strategy for the construction of site-selective protein bioconjugates. Here we describe the first examples of a new class of such reagents, containing a ‘stable-labile’ design. These dual-reactive reagents are designed to form a sta...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555722/ https://www.ncbi.nlm.nih.gov/pubmed/36320392 http://dx.doi.org/10.1039/d2sc04531a |