Collagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice

The osteogenesis imperfecta murine (oim) model with solely homotrimeric (α1)(3) type I collagen, owing to a dysfunctional α2(I) collagen chain, has a brittle bone phenotype, implying that the (α1)(2)(α2)(1) heterotrimer is required for physiological bone function. Here, we comprehensively show, for...

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Detalles Bibliográficos
Autores principales: Lee, Katie J., Rambault, Lisa, Bou-Gharios, George, Clegg, Peter D., Akhtar, Riaz, Czanner, Gabriela, van ‘t Hof, Rob, Canty-Laird, Elizabeth G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555767/
https://www.ncbi.nlm.nih.gov/pubmed/36106514
http://dx.doi.org/10.1242/dmm.049428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555767/
https://www.ncbi.nlm.nih.gov/pubmed/36106514
http://dx.doi.org/10.1242/dmm.049428

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