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Collagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice
The osteogenesis imperfecta murine (oim) model with solely homotrimeric (α1)(3) type I collagen, owing to a dysfunctional α2(I) collagen chain, has a brittle bone phenotype, implying that the (α1)(2)(α2)(1) heterotrimer is required for physiological bone function. Here, we comprehensively show, for...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Ltd
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555767/ https://www.ncbi.nlm.nih.gov/pubmed/36106514 http://dx.doi.org/10.1242/dmm.049428 |