A phenotypic rescue approach identifies lineage regionalization defects in a mouse model of DiGeorge syndrome

TBX1 is a key regulator of pharyngeal apparatus (PhAp) development. Vitamin B12 (vB12) treatment partially rescues aortic arch patterning defects of Tbx1(+/−) embryos. Here, we show that it also improves cardiac outflow tract septation and branchiomeric muscle anomalies of Tbx1 hypomorphic mutants....

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Detalles Bibliográficos
Autores principales: Lania, Gabriella, Franzese, Monica, Adachi, Noritaka, Bilio, Marchesa, Flore, Gemma, Russo, Annalaura, D'Agostino, Erika, Angelini, Claudia, Kelly, Robert G., Baldini, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555768/
https://www.ncbi.nlm.nih.gov/pubmed/35946435
http://dx.doi.org/10.1242/dmm.049415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555768/
https://www.ncbi.nlm.nih.gov/pubmed/35946435
http://dx.doi.org/10.1242/dmm.049415

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