PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR(B) GTPase domain

Leucine-rich-repeat-kinase 1 (LRRK1) and its homolog LRRK2 are multidomain kinases possessing a ROC-COR(A)-COR(B) containing GTPase domain and phosphorylate distinct Rab proteins. LRRK1 loss of function mutations cause the bone disorder osteosclerotic metaphyseal dysplasia, whereas LRRK2 missense mu...

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Detalles Bibliográficos
Autores principales: Malik, Asad U., Karapetsas, Athanasios, Nirujogi, Raja S., Chatterjee, Deep, Phung, Toan K., Wightman, Melanie, Gourlay, Robert, Morrice, Nick, Mathea, Sebastian, Knapp, Stefan, Alessi, Dario R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555798/
https://www.ncbi.nlm.nih.gov/pubmed/36040231
http://dx.doi.org/10.1042/BCJ20220308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555798/
https://www.ncbi.nlm.nih.gov/pubmed/36040231
http://dx.doi.org/10.1042/BCJ20220308

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