A Population Pharmacokinetic Modelling Approach to Unravel the Complex Pharmacokinetics of Vincristine in Children

BACKGROUND: Vincristine, a chemotherapeutic agent that extensively binds to β-tubulin, is commonly dosed at 1.4–2.0 mg/m(2) capped at 2 mg. For infants, doses vary from 0.025–0.05 mg/kg or 50–80% of the mg/m(2) dose. However, evidence for lower doses in infants compared to older children is lacking....

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Detalles Bibliográficos
Autores principales: Nijstad, A. Laura, Chu, Wan-Yu, de Vos-Kerkhof, Evelien, Enters-Weijnen, Catherine F., van de Velde, Mirjam E., Kaspers, Gertjan J. L., Barnett, Shelby, Veal, Gareth J., Lalmohamed, Arief, Zwaan, C. Michel, Huitema, Alwin D. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556337/
https://www.ncbi.nlm.nih.gov/pubmed/35986122
http://dx.doi.org/10.1007/s11095-022-03364-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556337/
https://www.ncbi.nlm.nih.gov/pubmed/35986122
http://dx.doi.org/10.1007/s11095-022-03364-1

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