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A Population Pharmacokinetic Modelling Approach to Unravel the Complex Pharmacokinetics of Vincristine in Children
BACKGROUND: Vincristine, a chemotherapeutic agent that extensively binds to β-tubulin, is commonly dosed at 1.4–2.0 mg/m(2) capped at 2 mg. For infants, doses vary from 0.025–0.05 mg/kg or 50–80% of the mg/m(2) dose. However, evidence for lower doses in infants compared to older children is lacking....
Autores principales: | Nijstad, A. Laura, Chu, Wan-Yu, de Vos-Kerkhof, Evelien, Enters-Weijnen, Catherine F., van de Velde, Mirjam E., Kaspers, Gertjan J. L., Barnett, Shelby, Veal, Gareth J., Lalmohamed, Arief, Zwaan, C. Michel, Huitema, Alwin D. R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556337/ https://www.ncbi.nlm.nih.gov/pubmed/35986122 http://dx.doi.org/10.1007/s11095-022-03364-1 |
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