Structural analysis of the overoxidized Cu/Zn-superoxide dismutase in ROS-induced ALS filament formation

Eukaryotic Cu, Zn-superoxide dismutase (SOD1) is primarily responsible for cytotoxic filament formation in amyotrophic lateral sclerosis (ALS) neurons. Two cysteine residues in SOD1 form an intramolecular disulfide bond. This study aims to explore the molecular mechanism of SOD1 filament formation b...

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Detalles Bibliográficos
Autores principales: Baek, Yeongjin, Woo, Tae-Gyun, Ahn, Jinsook, Lee, Dukwon, Kwon, Yonghoon, Park, Bum-Joon, Ha, Nam-Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556535/
https://www.ncbi.nlm.nih.gov/pubmed/36224351
http://dx.doi.org/10.1038/s42003-022-04017-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556535/
https://www.ncbi.nlm.nih.gov/pubmed/36224351
http://dx.doi.org/10.1038/s42003-022-04017-0

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