Predicting the structure of large protein complexes using AlphaFold and Monte Carlo tree search

AlphaFold can predict the structure of single- and multiple-chain proteins with very high accuracy. However, the accuracy decreases with the number of chains, and the available GPU memory limits the size of protein complexes which can be predicted. Here we show that one can predict the structure of...

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Detalles Bibliográficos
Autores principales: Bryant, Patrick, Pozzati, Gabriele, Zhu, Wensi, Shenoy, Aditi, Kundrotas, Petras, Elofsson, Arne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556563/
https://www.ncbi.nlm.nih.gov/pubmed/36224222
http://dx.doi.org/10.1038/s41467-022-33729-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556563/
https://www.ncbi.nlm.nih.gov/pubmed/36224222
http://dx.doi.org/10.1038/s41467-022-33729-4

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