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Resolving subcellular pH with a quantitative fluorescent lifetime biosensor

Changes in sub-cellular pH play a key role in metabolism, membrane transport, and triggering cargo release from therapeutic delivery systems. Most methods to measure pH rely on intensity changes of pH sensitive fluorophores, however, these measurements are hampered by high uncertainty in the inferre...

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Detalles Bibliográficos
Autores principales: Rennick, Joshua J., Nowell, Cameron J., Pouton, Colin W., Johnston, Angus P. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556823/
https://www.ncbi.nlm.nih.gov/pubmed/36224168
http://dx.doi.org/10.1038/s41467-022-33348-z