Ensemble origins and distance-dependence of long-range mutational effects in proteins

Mutational effects in globular proteins exhibit an exponential-like decreasing dependence on distance from the mutated site, suggestive of long-range modulation of structural-thermodynamic features. Here, we extract the physical origins of this pattern by employing a statistical-mechanical model to...

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Detalles Bibliográficos
Autores principales: Kannan, Adithi, Naganathan, Athi N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556916/
https://www.ncbi.nlm.nih.gov/pubmed/36248733
http://dx.doi.org/10.1016/j.isci.2022.105181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556916/
https://www.ncbi.nlm.nih.gov/pubmed/36248733
http://dx.doi.org/10.1016/j.isci.2022.105181

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