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Ensemble origins and distance-dependence of long-range mutational effects in proteins
Mutational effects in globular proteins exhibit an exponential-like decreasing dependence on distance from the mutated site, suggestive of long-range modulation of structural-thermodynamic features. Here, we extract the physical origins of this pattern by employing a statistical-mechanical model to...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556916/ https://www.ncbi.nlm.nih.gov/pubmed/36248733 http://dx.doi.org/10.1016/j.isci.2022.105181 |