Altered Behavioral Responses Show GABA Sensitivity in Muscleblind-Like 2-Deficient Mice: Implications for CNS Symptoms in Myotonic Dystrophy

Considerable evidence from mouse models and human postmortem brain suggests loss of Muscleblind-like protein 2 (MBNL2) function in brain is a major driver of CNS symptoms in Myotonic dystrophy type 1 (DM1). Increased hypersomnia, fatigue, and surgical complications associated with general anesthesia...

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Detalles Bibliográficos
Autores principales: Edokpolor, Kamyra S., Banerjee, Anwesha, McEachin, Zachary T., Gu, Jingsheng, Kosti, Adam, Arboleda, Juan D., García, Paul S., Wang, Eric T., Bassell, Gary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2022
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557336/
https://www.ncbi.nlm.nih.gov/pubmed/36150891
http://dx.doi.org/10.1523/ENEURO.0218-22.2022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557336/
https://www.ncbi.nlm.nih.gov/pubmed/36150891
http://dx.doi.org/10.1523/ENEURO.0218-22.2022

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