INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury

During early ischemic brain injury, glutamate receptor hyperactivation mediates neuronal death via osmotic cell swelling. Here we show that ischemia and excess NMDA receptor activation cause actin to rapidly and extensively reorganize within the somatodendritic compartment. Normally, F-actin is conc...

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Detalles Bibliográficos
Autores principales: Calabrese, Barbara, Jones, Steven L., Shiraishi-Yamaguchi, Yoko, Lingelbach, Michael, Manor, Uri, Svitkina, Tatyana M., Higgs, Henry N., Shih, Andy Y., Halpain, Shelley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558009/
https://www.ncbi.nlm.nih.gov/pubmed/36229429
http://dx.doi.org/10.1038/s41467-022-33268-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558009/
https://www.ncbi.nlm.nih.gov/pubmed/36229429
http://dx.doi.org/10.1038/s41467-022-33268-y

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