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INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury
During early ischemic brain injury, glutamate receptor hyperactivation mediates neuronal death via osmotic cell swelling. Here we show that ischemia and excess NMDA receptor activation cause actin to rapidly and extensively reorganize within the somatodendritic compartment. Normally, F-actin is conc...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558009/ https://www.ncbi.nlm.nih.gov/pubmed/36229429 http://dx.doi.org/10.1038/s41467-022-33268-y |