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The Influenza-Induced Pulmonary Inflammatory Exudate in Susceptible Tpl2-Deficient Mice Is Dictated by Type I IFN Signaling

The most prominent host response to viral infection is the production of type 1 interferons (T1 IFNs). One host regulator of the T1 IFNs is the serine-threonine kinase, tumor progression locus 2 (TPL2). We have previously demonstrated that Tpl2(−/−) mice succumb to infection with a low-pathogenicity...

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Detalles Bibliográficos
Autores principales: Latha, Krishna, Patel, Yesha, Rao, Sanjana, Watford, Wendy T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558022/
https://www.ncbi.nlm.nih.gov/pubmed/36227523
http://dx.doi.org/10.1007/s10753-022-01736-8