Modulation of urelumab glycosylation separates immune stimulatory activity from organ toxicity

Checkpoint control and immunomodulatory antibodies have become important tools for modulating tumor or self-reactive immune responses. A major issue preventing to make full use of the potential of these immunomodulatory antibodies are the severe side-effects, ranging from systemic cytokine release s...

Descripción completa

Detalles Bibliográficos
Autores principales: Reitinger, Carmen, Ipsen-Escobedo, Andrea, Hornung, Chiara, Heger, Lukas, Dudziak, Diana, Lux, Anja, Nimmerjahn, Falk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558126/
https://www.ncbi.nlm.nih.gov/pubmed/36248847
http://dx.doi.org/10.3389/fimmu.2022.970290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558126/
https://www.ncbi.nlm.nih.gov/pubmed/36248847
http://dx.doi.org/10.3389/fimmu.2022.970290

Ejemplares similares