Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma

Chimeric fusion transcription factors are oncogenic hallmarks of several devastating cancer entities including pediatric sarcomas, such as Ewing sarcoma (EwS) and alveolar rhabdomyosarcoma (ARMS). Despite their exquisite specificity, these driver oncogenes have been considered largely undruggable du...

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Detalles Bibliográficos
Autores principales: Hölting, Tilman L. B., Cidre-Aranaz, Florencia, Matzek, Dana, Popper, Bastian, Jacobi, Severin J., Funk, Cornelius M., Geyer, Florian H., Li, Jing, Piseddu, Ignazio, Cadilha, Bruno L., Ledderose, Stephan, Zwilling, Jennifer, Ohmura, Shunya, Anz, David, Künkele, Annette, Klauschen, Frederick, Grünewald, Thomas G. P., Knott, Maximilian M. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558418/
https://www.ncbi.nlm.nih.gov/pubmed/36229873
http://dx.doi.org/10.1186/s12943-022-01641-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558418/
https://www.ncbi.nlm.nih.gov/pubmed/36229873
http://dx.doi.org/10.1186/s12943-022-01641-6

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