A non‐metabolic function of hexokinase 2 in small cell lung cancer: promotes cancer cell stemness by increasing USP11‐mediated CD133 stability

BACKGROUND: Maintenance of cancer stem‐like cell (CSC) stemness supported by aberrantly regulated cancer cell metabolism is critical for CSC self‐renewal and tumor progression. As a key glycolytic enzyme, hexokinase 2 (HK2) plays an instrumental role in aerobic glycolysis and tumor progression. Howe...

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Detalles Bibliográficos
Autores principales: Wang, Juhong, Shao, Fei, Yang, Yannan, Wang, Wei, Yang, Xueying, Li, Renda, Cheng, Hong, Sun, Sijin, Feng, Xiaoli, Gao, Yibo, He, Jie, Lu, Zhimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558687/
https://www.ncbi.nlm.nih.gov/pubmed/35975322
http://dx.doi.org/10.1002/cac2.12351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558687/
https://www.ncbi.nlm.nih.gov/pubmed/35975322
http://dx.doi.org/10.1002/cac2.12351

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