Cargando…
Zinc enhances autophagic flux and lysosomal function through transcription factor EB activation and V-ATPase assembly
The stimulation of autophagy or lysosomes has been considered therapeutic for neurodegenerative disorders because the accumulation of misfolded proteins is commonly observed in the brains of individuals with these diseases. Although zinc is known to play critical roles in the functions of lysosomes...
Autores principales: | Kim, Ki-Ryeong, Park, Sang Eun, Hong, Ji-Ye, Koh, Jae-Young, Cho, Dong-Hyung, Hwang, Jung Jin, Kim, Yang-Hee |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558701/ https://www.ncbi.nlm.nih.gov/pubmed/36246521 http://dx.doi.org/10.3389/fncel.2022.895750 |
Ejemplares similares
-
Enhancing lysosomal biogenesis and autophagic flux by activating the transcription factor EB protects against cadmium-induced neurotoxicity
por: Pi, Huifeng, et al.
Publicado: (2017) -
RORα Enhances Lysosomal Acidification and Autophagic Flux in the Hepatocytes
por: Kim, Hyeon‐Ji, et al.
Publicado: (2021) -
Impaired Autophagic Flux in Glucose-Deprived Cells: An Outcome of Lysosomal Acidification Failure Exacerbated by Mitophagy Dysfunction
por: Hwang, Eun Seong, et al.
Publicado: (2023) -
Triamterene induces autophagic degradation of lysosome by exacerbating lysosomal integrity
por: Park, Na Yeon, et al.
Publicado: (2021) -
Targeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics
por: Miyazaki, Masaya, et al.
Publicado: (2021)