Immobilization-Free Binding and Affinity Characterization of Higher Order Bispecific Antibody Complexes Using Size-Based Microfluidics

[Image: see text] Simultaneous targeting of different antigens by bispecific antibodies (bsAbs) is permitting synergistic binding functionalities with high therapeutic potential, but is also rendering their analysis challenging. We introduce flow-induced dispersion analysis (FIDA) for the in-depth c...

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Detalles Bibliográficos
Autores principales: Madsen, Andreas V., Mejias-Gomez, Oscar, Pedersen, Lasse E., Skovgaard, Kerstin, Kristensen, Peter, Goletz, Steffen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558742/
https://www.ncbi.nlm.nih.gov/pubmed/36166291
http://dx.doi.org/10.1021/acs.analchem.2c02705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558742/
https://www.ncbi.nlm.nih.gov/pubmed/36166291
http://dx.doi.org/10.1021/acs.analchem.2c02705

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