CRISPR/Cas9-mediated deletion of Interleukin-30 suppresses IGF1 and CXCL5 and boosts SOCS3 reducing prostate cancer growth and mortality

BACKGROUND: Metastatic prostate cancer (PC) is a leading cause of cancer death in men worldwide. Targeting of the culprits of disease progression is an unmet need. Interleukin (IL)-30 promotes PC onset and development, but whether it can be a suitable therapeutic target remains to be investigated. H...

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Detalles Bibliográficos
Autores principales: Sorrentino, Carlo, D’Antonio, Luigi, Ciummo, Stefania Livia, Fieni, Cristiano, Landuzzi, Lorena, Ruzzi, Francesca, Vespa, Simone, Lanuti, Paola, Lotti, Lavinia Vittoria, Lollini, Pier Luigi, Di Carlo, Emma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559017/
https://www.ncbi.nlm.nih.gov/pubmed/36224639
http://dx.doi.org/10.1186/s13045-022-01357-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559017/
https://www.ncbi.nlm.nih.gov/pubmed/36224639
http://dx.doi.org/10.1186/s13045-022-01357-6

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