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Estimating the effect size of a hidden causal factor between SNPs and a continuous trait: a mediation model approach

BACKGROUND: Observational studies and Mendelian randomization experiments have been used to identify many causal factors for complex traits in humans. Given a set of causal factors, it is important to understand the extent to which these causal factors explain some, all, or none of the genetic herit...

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Detalles Bibliográficos
Autores principales: Ding, Zhuoran, Ritchie, Marylyn D., Voight, Benjamin F., Hwang, Wei-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559019/
https://www.ncbi.nlm.nih.gov/pubmed/36229773
http://dx.doi.org/10.1186/s12859-022-04977-4