High-Level MYCN-Amplified RB1-Proficient Retinoblastoma Tumors Retain Distinct Molecular Signatures

PURPOSE: Retinoblastomas are malignant eye tumors diagnosed in young children. Most retinoblastomas are genetically characterized by biallelic inactivation of the RB1 gene. However, 1.5% of tumors demonstrate high-level amplification of the proto-oncogene MYCN. Patients with MYCN-amplified RB1-profi...

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Detalles Bibliográficos
Autores principales: Roohollahi, Khashayar, de Jong, Yvonne, van Mil, Saskia E., Fabius, Armida W.M., Moll, Annette C., Dorsman, Josephine C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559112/
https://www.ncbi.nlm.nih.gov/pubmed/36245757
http://dx.doi.org/10.1016/j.xops.2022.100188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559112/
https://www.ncbi.nlm.nih.gov/pubmed/36245757
http://dx.doi.org/10.1016/j.xops.2022.100188

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