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The gastrointestinal and microbiome impact of a resistant starch blend from potato, banana, and apple fibers: A randomized clinical trial using smart caps

The gastrointestinal (GI) impact of fibers including resistant starch (RS) consumption depends on various types and amounts of fibers, the initial microbiome states, and accurate intake measurements. A randomized clinical trial evaluated the GI impact of varying doses of a novel resistant starch ble...

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Autores principales: Hanes, Douglas, Nowinski, Brent, Lamb, Joseph J., Larson, Ilona A., McDonald, Daniel, Knight, Rob, Song, Se Jin, Patno, Noelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559413/
https://www.ncbi.nlm.nih.gov/pubmed/36245486
http://dx.doi.org/10.3389/fnut.2022.987216
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author Hanes, Douglas
Nowinski, Brent
Lamb, Joseph J.
Larson, Ilona A.
McDonald, Daniel
Knight, Rob
Song, Se Jin
Patno, Noelle
author_facet Hanes, Douglas
Nowinski, Brent
Lamb, Joseph J.
Larson, Ilona A.
McDonald, Daniel
Knight, Rob
Song, Se Jin
Patno, Noelle
author_sort Hanes, Douglas
collection PubMed
description The gastrointestinal (GI) impact of fibers including resistant starch (RS) consumption depends on various types and amounts of fibers, the initial microbiome states, and accurate intake measurements. A randomized clinical trial evaluated the GI impact of varying doses of a novel resistant starch blend (RSB) with smart cap monitoring. RSB contained at least 50% RS and was a proprietary mixture of a potato starch, green banana flour, and apple fiber powder (a source of apple pectin, not resistant starch). The study design randomized participants to one of four arms: 10 g/day of potato starch (0 RSB), 10 g/day of RSB, 10 to 20 to 20 g/day of RSB or 10 to 20 to 30 g/day RSB for two-week intervals over 6 weeks. Results confirmed that while resistant starch of approximately 5 g per day improves GI symptoms at 2, 4, and 6 weeks, it did not demonstrate a detectable effect on short chain fatty acids. Increasing doses of the blend (RSB) led to a decrease in the diarrhea score. Using an estimate of total consumption of RSB based on smart cap recordings of container openings and protocol-specified doses of RSB, a reduction in the sleep disturbance score was associated with higher RSB dose. The exploratory microbiome evaluation demonstrated that among the 16S rRNA gene sequences most associated with the consumption of the novel blend RSB, two belong to taxa of notable interest to human health: Faecalibacterium and Akkermansia.
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spelling pubmed-95594132022-10-14 The gastrointestinal and microbiome impact of a resistant starch blend from potato, banana, and apple fibers: A randomized clinical trial using smart caps Hanes, Douglas Nowinski, Brent Lamb, Joseph J. Larson, Ilona A. McDonald, Daniel Knight, Rob Song, Se Jin Patno, Noelle Front Nutr Nutrition The gastrointestinal (GI) impact of fibers including resistant starch (RS) consumption depends on various types and amounts of fibers, the initial microbiome states, and accurate intake measurements. A randomized clinical trial evaluated the GI impact of varying doses of a novel resistant starch blend (RSB) with smart cap monitoring. RSB contained at least 50% RS and was a proprietary mixture of a potato starch, green banana flour, and apple fiber powder (a source of apple pectin, not resistant starch). The study design randomized participants to one of four arms: 10 g/day of potato starch (0 RSB), 10 g/day of RSB, 10 to 20 to 20 g/day of RSB or 10 to 20 to 30 g/day RSB for two-week intervals over 6 weeks. Results confirmed that while resistant starch of approximately 5 g per day improves GI symptoms at 2, 4, and 6 weeks, it did not demonstrate a detectable effect on short chain fatty acids. Increasing doses of the blend (RSB) led to a decrease in the diarrhea score. Using an estimate of total consumption of RSB based on smart cap recordings of container openings and protocol-specified doses of RSB, a reduction in the sleep disturbance score was associated with higher RSB dose. The exploratory microbiome evaluation demonstrated that among the 16S rRNA gene sequences most associated with the consumption of the novel blend RSB, two belong to taxa of notable interest to human health: Faecalibacterium and Akkermansia. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9559413/ /pubmed/36245486 http://dx.doi.org/10.3389/fnut.2022.987216 Text en Copyright © 2022 Hanes, Nowinski, Lamb, Larson, McDonald, Knight, Song and Patno. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Hanes, Douglas
Nowinski, Brent
Lamb, Joseph J.
Larson, Ilona A.
McDonald, Daniel
Knight, Rob
Song, Se Jin
Patno, Noelle
The gastrointestinal and microbiome impact of a resistant starch blend from potato, banana, and apple fibers: A randomized clinical trial using smart caps
title The gastrointestinal and microbiome impact of a resistant starch blend from potato, banana, and apple fibers: A randomized clinical trial using smart caps
title_full The gastrointestinal and microbiome impact of a resistant starch blend from potato, banana, and apple fibers: A randomized clinical trial using smart caps
title_fullStr The gastrointestinal and microbiome impact of a resistant starch blend from potato, banana, and apple fibers: A randomized clinical trial using smart caps
title_full_unstemmed The gastrointestinal and microbiome impact of a resistant starch blend from potato, banana, and apple fibers: A randomized clinical trial using smart caps
title_short The gastrointestinal and microbiome impact of a resistant starch blend from potato, banana, and apple fibers: A randomized clinical trial using smart caps
title_sort gastrointestinal and microbiome impact of a resistant starch blend from potato, banana, and apple fibers: a randomized clinical trial using smart caps
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559413/
https://www.ncbi.nlm.nih.gov/pubmed/36245486
http://dx.doi.org/10.3389/fnut.2022.987216
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