Dependence on linkers’ flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents

Herein we reported the design and synthesis of two series comprising twenty-two benzenesulfonamides that integrate the s-triazine moiety. Target compounds successfully suppressed the hCA IX, with IC(50) ranging from 28.6 to 871 nM. Compounds 5d, 11b, 5b, and 7b were the most active analogues, which...

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Detalles Bibliográficos
Autores principales: Tawfik, Haytham O., Belal, Amany, Abourehab, Mohammed A. S., Angeli, Andrea, Bonardi, Alessandro, Supuran, Claudiu T., El-Hamamsy, Mervat H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559471/
https://www.ncbi.nlm.nih.gov/pubmed/36210545
http://dx.doi.org/10.1080/14756366.2022.2130285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559471/
https://www.ncbi.nlm.nih.gov/pubmed/36210545
http://dx.doi.org/10.1080/14756366.2022.2130285

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