High phenylalanine concentrations induce demyelination and microglial activation in mouse cerebellar organotypic slices

Phenylketonuria (PKU) is an inborn error of metabolism. Mutations in the enzyme phenylalanine hydroxylase (PAH)-encoding gene lead to a decreased metabolism of the amino acid phenylalanine (Phe). The deficiency in PAH increases Phe levels in blood and brain. Accumulation of Phe can lead to delayed d...

Descripción completa

Detalles Bibliográficos
Autores principales: Thau-Zuchman, Orli, Pallier, Patrick N., Savelkoul, Paul J. M., Kuipers, Almar A. M., Verkuyl, J. Martin, Michael-Titus, Adina T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559601/
https://www.ncbi.nlm.nih.gov/pubmed/36248632
http://dx.doi.org/10.3389/fnins.2022.926023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559601/
https://www.ncbi.nlm.nih.gov/pubmed/36248632
http://dx.doi.org/10.3389/fnins.2022.926023

Ejemplares similares